We used a reverse vaccinology approach to identify 66 Mmm potential vaccine candidates. The selection and grouping of the antigens was based on the presence of specific antibodies in sera from CBPP-positive animals. The antigens were used to immunize male Boran cattle (Bos indicus) followed by a challenge with the Mmm strain Afadé.
A new study published in the science journal Emerging Infectious Diseases reports that two individuals in Kenya have tested positive for the presence of antibodies to Middle East Respiratory Syndrome Corona Virus (MERS-CoV). Neither person is ill nor do they recall having any symptoms associated with MERS. There is no evidence of a public health threat and scientists concluded that the infections caused little or no clinical signs of illness. But they plan follow-up studies, as this is the first indication of a MERS-CoV infection that is not connected to primary infections in the Middle East.