Tremendous research progress has been made over the last ten years to better control the deadly African disease of cattle known as East Coast fever. This disease is caused by a single-celled organism, Theileria parva, which is carried by some tick species. Cattle become infected when a tick carrying the parasite takes a blood-meal from the animal over several days.
Today and tomorrow (31 May–1 Jun 2016), Chatham House, the Livestock Global Alliance (LGA), the One Health Platform and other One Health partners are convening senior policymakers, academics, multilateral development agencies, business leaders and other private-sector stakeholders to discuss livestock’s role in poverty reduction, sustainable livestock production systems, innovations in livestock vaccines and diagnostics and the value of establishing national and regional One Health centres to provide advice on links among agriculture, sustainable livestock systems and human development.
We used a reverse vaccinology approach to identify 66 Mmm potential vaccine candidates. The selection and grouping of the antigens was based on the presence of specific antibodies in sera from CBPP-positive animals. The antigens were used to immunize male Boran cattle (Bos indicus) followed by a challenge with the Mmm strain Afadé.
With colleagues from the Jenner and Pirbright institutes in the UK, Nairobi’s Strathmore University and institutions in Saudi Arabia and Spain, scientists and technicians in a vaccine biosciences program of the International Livestock Research Institute (ILRI) in Nairobi, Kenya, have recently published a paper in Nature announcing a breakthrough in development of a ‘One Health’ vaccine that could protect both people and livestock from Rift Valley fever.
For almost thirty years, the International Laboratory for Research on Animal Diseases (ILRAD) then ILRI benefited from a strong research program in the epidemiological sciences. Over time, it progressively broadened its coverage in disease, disciplinary and geographic terms. The results of this work have now been assembled in this impact narrative, which carefully documents the wide range of issues addressed by the teams of researchers, and presents them in an illustrated and highly readable format.
Researchers have received a grant from the Bill & Melinda Gates Foundation to develop anew-generation vaccine for East Coast fever. which could inform malaria and cancer research.